Abstract :Bronchial asthma is a chronic disease characterized by airway inflammation, hyperresponsiveness
and remodeling. Most patients can achieve adequate control of asthma while the subgroup
shows little reaction to current treatment is defined as ‘severe asthma’. Efforts have been made by
researchers to reveal a more exact definition, a more specific mechanism and an efficient individual
therapy. This review will provide an update on the latest advancements with regard to all these
domains.